A Cardiologist With Alzheimer’s in His Family Just Started Taking This. Here’s the 20-Year Research That Made Him Decide.
Dr. Peter McCullough has over 1,000 peer-reviewed publications. His father died with Alzheimer’s. His mother is in memory care. When he reviewed the published findings from Dr. John E. Lewis’s landmark clinical trial, he made a personal decision — and said so publicly on his Substack, which reaches hundreds of thousands of readers.
If you have watched someone you love lose their mind — slowly, then completely — you already understand why this research matters. If you haven’t, the statistics suggest you will. An estimated 14 to 15 million Americans currently have Alzheimer’s or another form of dementia. The annual cost of care runs between $500 billion and $1 trillion. The average gap between the end of a person’s health span and the end of their life is now 11 years, according to research published in JAMA.
Dr. McCullough knows this not as a statistic but as a daily reality. His father died with Alzheimer’s — forgetting to eat, losing 60 pounds, found dead in his sleep. His mother is currently in a memory care unit requiring 24-hour care. His wife’s mother lives in their home. When McCullough, a cardiologist with over 1,000 peer-reviewed publications, encountered Dr. John E. Lewis’s published research, his response was not academic. It was personal.
This is the research he was responding to.
The Study That Made a Journal Editor Call Dr. Lewis Personally
The phone rang in Dr. John E. Lewis’s office at the University of Miami Miller School of Medicine. It was the editor of the Journal of Alzheimer’s Disease.
“Wow, Dr. Lewis, this paper is amazing. As soon as I get the reviews back, I am going to publish this immediately.”
It was the only time in Lewis’s career a journal editor had called him. The results warranted it. Four peer-reviewed papers would come from that single 12-month trial.
Lewis had spent 20 years as a researcher at the University of Miami Miller School of Medicine, designing controlled clinical trials, publishing peer-reviewed science, and raising or supporting raising over $23 million in research funding. He devoted most of that career to a single question:
The answer kept returning to something most Americans had never heard of: polysaccharides. Long-chain complex carbohydrates found in high concentrations in two ancient plant sources — aloe vera and rice bran — that are almost entirely absent from the modern American diet.
Aloe vera: The gel products at your pharmacy are roughly 99% water. Therapeutic polysaccharide concentrations require extraction and standardization that no commercial aloe product provides.
Rice bran: Found only in the outer layer of brown rice, removed entirely during white rice processing. Fewer than 30% of Americans eat brown rice regularly.
The result: Most Americans get essentially zero dietary polysaccharides from either source — not because the plants are rare, but because of how we process food.
In 2013, Lewis and colleagues published the results of a 12-month clinical trial in the Journal of Alzheimer’s Disease. Thirty-four participants with moderate-to-severe Alzheimer’s. No changes to diet, medication, exercise, or behavior — the only variable was the addition of a concentrated polysaccharide multinutrient formula. Cognitive function was assessed every three months using the ADAS-cog, the gold-standard tool for measuring cognitive change in dementia research.
Lewis JE, McDaniel HR, Agronin ME, et al. “The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease.” Journal of Alzheimer’s Disease. 2013;33(2):393–406. doi: 10.3233/JAD-2012-121381. — Scientific basis for formulation. Not a claim about Daily Brain Care consumer results. Not evaluated by FDA.
At nine and twelve months, the data showed clinically and statistically significant improvements in cognitive function — a result that, as McCullough confirmed on the podcast, has no equivalent in the published literature for any dietary supplement, FDA-approved drug, or other intervention in this disease population. The study also showed a 286% increase in CD14+ adult stem cell production, significant reductions in inflammatory markers TNF-α and VEGF, and improved overall immune function.
The study neuropsychologist, Dr. Mairelys Martinez, Ph.D., assessed the outcome plainly:
Lewis et al., J Alzheimers Dis. 2013;33(2):393–406 · Individual consumer results will vary · Not evaluated by FDA
He Applied for Follow-Up Funding. Four Times. Rejected Each Time.
The result made the journal editor call. It did not make the funding system respond. Lewis applied to the NIH. He applied to the Alzheimer’s Association. He was rejected twice by each organization. The reason is not mysterious.
Research funding flows toward compounds that can be patented. Patented compounds become drugs. Drugs generate revenue. Naturally occurring polysaccharides from aloe vera and rice bran cannot be patented. No patent, no financial incentive, no follow-up trial.
“I said: why am I going to continue banging my head against the wall? It was going from literally cloud nine to not even in the valley — but under the valley.”
— Dr. John E. Lewis, on The McCullough Report
The data were in the journals. The peer review had passed. The system that was supposed to fund the next step was not interested because no patent was at the end of the road. Lewis spent two more years at the university. Then he left and built the product himself.
One of America’s Most Published Cardiologists Reviews the Data — Then Makes It Personal
Dr. Peter McCullough, M.D., M.P.H. is a board-certified cardiologist with over 1,000 peer-reviewed publications. He is not a neurologist and was not involved in the research. When Dr. Lewis appeared on The McCullough Report on America Out Loud and walked through the published findings, McCullough’s reaction covered two things: the science, and something more personal.
On reviewing the study data, McCullough described the ADAS-cog results as “astounding” and “unheard of,” and confirmed from his own reading of the literature that no equivalent result exists for any supplement, drug, or intervention in this disease population. He also validated the study design: paired data, each person serving as their own internal control, assessed by the same neuropsychologist at each time point.
“I have it at work. I just put it in a small amount of water, stir it up, and drink it quickly. It tastes good. And the other thing I noticed — it takes an edge off my hunger.”
“I am doing all the other things: I do not drink alcohol, I exercise, I keep myself mentally very active. And psychologically, I feel better now thanks to Dr. Lewis — that I am doing something about this.”
Personal statements. Not medical advice. Not a claim that Daily Brain Care treats any condition. Not evaluated by FDA.
So Dr. Lewis did what the research funding system would not. He built a product. Not a pharmaceutical. Not a cure. A dietary supplement, formulated from the same polysaccharide compound classes he spent 20 years studying, manufactured in a GMP-certified U.S. facility. Every ingredient has a physiological purpose backed by the published literature.*
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily Brain Care is a dietary supplement for generally healthy adults seeking to support everyday cognitive function, mental clarity, and immune health. It is not a drug. It is not intended for people with diagnosed medical conditions. Please consult a qualified physician before beginning any supplement.
These statements have not been evaluated by the FDA. Daily Brain Care is not intended to diagnose, treat, cure, or prevent any disease.
Clean, Science-Backed Support for Everyday Cognitive Wellness
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results will vary.
Twenty years of published research. A scientist who takes it every day. A cardiologist who just started — and said so publicly.
See Daily Brain Care →The Industry Built on Marketing. The One Built on Science.
| Most Brain Supplements | Daily Brain Care |
|---|---|
| ✕ Created by marketers; ingredients sourced to fit a trend | ✓ Formulated by a researcher with 180+ publications and 30+ clinical trials |
| ✕ No published peer-reviewed research behind the formulation | ✓ Ingredients backed by published peer-reviewed research you can verify |
| ✕ Founder has no clinical research history with the ingredients | ✓ Founder has taken it every single day for over a decade |
| ✕ 30-day return — before most people have evaluated anything | ✓ 60-day money-back guarantee · GMP-certified U.S. facility |
Eleven Ingredients. Every One There for a Physiological Reason.
No stimulants. No caffeine. No ingredients added for label appeal. Two principal active compounds supported by nine complementary whole food ingredients.
* These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results will vary.
The specific combination and concentrations reflect 20 years of academic research and remain proprietary to Dr Lewis Nutrition®. Every ingredient has a physiological purpose backed by the published literature — not because it looks good on a label or because it is trending in the supplement category.
The Physicians and Pharmacists Who Recommend It
The following statements are from licensed healthcare professionals who reviewed the published research and chose to recommend Daily Brain Care in their clinical practice. These are professional assessments based on published research and individual clinical experience. They are not a claim that Daily Brain Care treats or prevents any medical condition. Individual results will vary. Not evaluated by FDA.
From People Who Did Their Homework Before They Did Business
Individual results vary significantly. Most customers will not experience the specific improvements described below. Daily Brain Care supports general cognitive wellness in healthy adults — it is not a treatment for any medical condition. Testimonials are self-reported personal experiences, not verified medical outcomes.
Polysaccharides support the body cumulatively. Most customers notice something within the first few weeks — but a genuine personal evaluation takes 90 days. Dr. Lewis has taken Daily Brain Care every single day for over a decade. Dr. McCullough is in his first year. We recommend starting with at least three months. Our 60-day guarantee means you can return it before that window closes, no questions asked.*
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results will vary.
Try Daily Brain Care for two full months. If you don’t feel a difference in focus, mental clarity, or cognitive wellness, simply contact us within 60 days for a full refund. No questions asked.
What Readers Ask Most
Thousands of supplements are on the market. Almost no company built one the way Lewis did — starting with two decades of published research, running the trials himself, watching the funding dry up, and deciding that the people who needed this information deserved better than a journal article they would never read.
He takes it every day. Has for over a decade. A cardiologist with his own family history just started. Not because either of them is promoting it, but because the science earned the decision.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results will vary.
That is not a promise. It is a track record. And the 60-day guarantee means the only risk is not finding out.
Lewis JE, McDaniel HR, Agronin ME, et al. “The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease.” Journal of Alzheimer’s Disease. 2013;33(2):393–406. doi: 10.3233/JAD-2012-121381. PubMed PMID: 22976077. Presented as scientific background for formulation. Not evaluated by FDA.
McCullough PA, Lewis JE. “Reclaiming Your Mind.” Focal Points Substack / The McCullough Report, America Out Loud. May 2, 2026. Dr. McCullough’s statements reflect personal health choices and professional assessment of published research. Not a clinical endorsement.
Chapin D. “Could a Carbohydrate Cure Alzheimer’s?” The Epoch Times, Mind & Body. August 7, 2023. Independent editorial journalism. Not an endorsement of this product.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. Daily Brain Care is not intended to diagnose, treat, cure, or prevent any disease.
Clinical Research Disclaimer: References to published clinical research describe studies conducted on specific populations under controlled conditions. Results are presented as scientific background for the formulation, not as predictions of what individual consumers will experience. Individual results will vary.
Testimonial Disclaimer: Testimonials reflect personal experiences of individual customers and are not intended to represent or guarantee that any other person will achieve the same or comparable results. Individual results will vary significantly.
Sponsored Content: This page is sponsored content published by Dr Lewis Nutrition®. It is not published by or affiliated with The Epoch Times. References to The Epoch Times reflect prior independent editorial coverage (August 7, 2023) and do not imply endorsement of this product by The Epoch Times.
McCullough Disclosure: Dr. McCullough is not a paid spokesperson for Dr Lewis Nutrition® and has received no monetary compensation. His statements reflect personal health choices and professional assessment of published peer-reviewed research. They do not constitute a clinical endorsement for any specific health condition.
Pricing: The regular price of $240.00 for the 6-bottle supply reflects six individual bottles at the standard single-bottle retail price of $40.00 each.
Physician Consultation: Always consult your healthcare provider before beginning any new supplement regimen, particularly if you have a diagnosed medical condition, are pregnant or nursing, or are taking prescription medications.